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Noun(1) a variation in circumstances or fortune at different times in your life or in the development of something(2) mutability in life or nature (especially successive alternation from one condition to another(3) mutability in life or nature (especially successive alternation from one condition to another)(4) change

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(1) the vicissitude of the seasons(2) The concern for security was also a major point when I moved in three years ago (more on its vicissitudes later).(3) A vicissitudinous branch of American art - itself oftentimes viewed throughout its history as globally marginal and mutable, according to Wanda M. Corn's critically important essay.(4) Mick seems typical of those noble people, the ethnic Irish in Britain, who retain a love of Ireland and face life's vicissitudes with a smile.(5) However, such were the vicissitudes of English fortunes that the link with wealth was far more complex than King and Defoe appeared to recognize.(6) This contrast underscores the insulation which the Indian economy had enjoyed from the vicissitudes of world capitalism.(7) If that isn't an antidote to the vicissitudes of life, then what is?(8) If they speak to women readers of their personal vicissitudes in a way that is helpful, if they offer incantations for women to use in time of trouble, so much the better.(9) If there's a common thread running through Payne's films it is a strong sardonic sense of humour through which characters embrace life's vicissitudes .(10) He is as sharp a chronicler of the vicissitudes of love as he ever was.(11) Their crass intrusion into these areas as the face of public authority claiming to protect women from the vicissitudes of interpersonal strife is destined to end in disaster.(12) He took refuge in booze and the beginnings of drug availability, and was headed, if not for catastrophe, at least for significant vicissitudes .(13) Governments cannot protect citizens from all the circumstances and vicissitudes of life.(14) In any event, Malley began playing open stages, where crowds enthusiastically applauded her take on the vicissitudes of love.(15) This was partly because, prior to these decades of vicissitudes , the early modern traditions were well established.(16) Once again we see how the fortunes of modern European science intertwined with the vicissitudes of colonial expansion.